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Datasheet
Monoclonal Antibody to CD207/Langerin (Clone 929F3.01) Alexa 546 Conjugated
Cat.No DDX0362A546
Description CD207/Langerin
Format Alexa Fluor® 546
Unit 0.1 mg
Price(USD) 455.00
MSDS N/A
Catalog No
:
DDX0362A546
Contents
:
100 µg in 200 µl PBS 50% glycerol
Isotype
:
IgG2a
Clone
:
929F3.01
Purification
:
Purified using a QMA Hyper D ion exchange column
Species
:
Human, Mouse, Rat
Host
:
Rat
Supplier
:
Dendritics
Market Availability
:
North America (United States & Canada)
Application
IF/ICC: 5-20 ug/ml* see (Douillard P, 2005 J Invest Dermatol, 125: 983) Storage Aliquot and store at -20°C, protected from light. Contains no preservative; KEEP STERILE; AVOID REPEATED FREEZE/THAW CYCLES.
Background Langerin/CD207 is a transmembrane C-type lectin receptor (CLR) of epidermal and mucosal Langerhans cells (LCs) that induces Birbeck granule formation. Langerin features a single carbohydrate recognition domain (CRD) with mannose-type specificity in its extracellular portion. Langerin is unique among the CLRs in that it contains an intracellular domain with a proline-rich motif. Langerin expression has not been reported outside the DC system.
Antigen
In vitro-derived human DCs from CD34+cells (GMCSF+TNFalpha)
Application Notes
*Optimal dilution should be determined by each laboratory for each application
Immunofluorescence on mouse epidermal LC CD11c+ using 929F3.01.
IHC on human skin with 929F3.01-HRP.
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Related Products
Reference 1. Valladeau J et al, 2002 J Immunol, 168 : 782-792 2. Douillard P et al, 2005 J Invest Dermatol, 125: 983–994
Research purposes only.
Not for diagnostic or in vivo use. Alexa Fluor® is a registered trademark of Molecular Probes, Inc. IMGENEX sells Alexa Fluor® dye conjugated antibodies under license from Molecular Probes, Inc. for research use only.
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DDX0362A546 [Monoclonal Antibody to CD207/Langerin (Clone 929F3.01) Alexa 546 Conjugated]
