Apoptosis Programmed Cell Death Coined in the 1960's, "apoptosis" is derived from the Greek word apopiptein which means to fall off from. Apoptosis can be induced by a number of stimuli including UV damage, irradiation, drug treatment, or tumor necrosis factor. Once induced, apoptosis can, in turn, act through a number of different cell death signaling pathways.  The number of apoptosis and 'programmed cell death' related kits and reagents available to the market has increased significantly over the last few years.  This is in large part the result of increasing evidence implicating the role of apoptosis in a number of significantly relevant disease processes including certain autoimmune diseases, transplantation rejection, and neurodegenerative diseases. IMGENEX offers over 200 Apoptosis related antibodies, as well as ELISA kits, caspase inhibitors, active caspase detection kits, apoptosis detection kits, and mitochondrial permeability detection kits.     •  Apoptosis Related Antibodies   •  ELISA Assays   •  Caspase Inhibitors   •  Caspase Activity Assays     •  Mitochondrial Permeability Assays   •  Serine Protease Activity Assays   •  Plasmid & Synthetic siRNA Kits A Sample of IMGENEX's Apoptosis Related Antibodies (View all Apoptosis Antibodies)  Specificity Host React App. Apaf-1 Rabbit H, M, R WB Bcl-2 Multiple Hosts H WB, Flow, IHC BCL-6 Rabbit H, M WB Bif-1 Mouse H WB Bik Mouse H WB Bim/BOD  Mouse H, M, R WB BLyS/BAFF/THANK/TALL-1 Rabbit H, M WB Caspase-1 Multiple H WB, IHC Caspase-3 Mouse H WB, Flow, IP, IHC Caspase-3, Pro & Active/ Cleaved Forms Mouse H, M WB Caspase-8 Mouse H WB Caspase-12 Rabbit H, M, R WB Cytochrome C Mouse Multi WB, IHC IP DNA-PK Rabbit H, M, R WB, FC, IP HtrA2/Omi Mouse H WB, IHC Livin/IAP Mouse H WB Noxa Multiple H, M, R WB p53 Multiple Multiple WB, IHC, IP, ChIP, Gel Shift p53 phospho (Ser392) Rabbit H, M, R WB p73 Mouse H, M WB, IHC, IP, IF/ICC PUMA, PUMA a PUMA a/b PUMA a/d/g   Rabbit H, M WB, IHC RANK/TNF11aR/ODFR Mouse, Rabbit H, M WB, Flow RANK Mouse H, M WB, Flow, IP ROCK-1-Cleaved Mouse Broad WB Smac/DIABLO Rabbit H WB, IHC STAT6 Rabbit H WB STAT6-phosphospecific (Y641) Mouse H, M WB, IP UBE2N Rabbit H WB, IP Ubiquitin Multiple Broad WB, IHC, IF/ICC UNG Rabbit H, M, R WB XAF1 Rabbit H WB, IHC Caspase Inhibitors Caspase inhibitors are key research tools for  studying and manipulating apoptosis processes. IMGENEX offers a broad range of broad-spectrum and Caspase specific inhibitors.   Inhibitor Specificity Q-VD-OPH Broad-Spectrum Z-VAD-FMK Broad-Spectrum BOC-D-FMK Broad-Spectrum Z-DEVD-FMK Caspase-3/7 Z-IETD-FMK Caspase-8 Z-LEHD-FMK Caspase-9   Caspase Activity Detection Assays Fluorochrome labeled Caspase inhibitors are novel tools for detecting and quantitating caspase activation in living cells by intracellular flow cytometry, fluorescence microscopy, and 96-well fluorescence plate format.    •  Potent anti-apoptotic properties   •  Non-toxic   •  Cell permeable   •  Useful for quantitative analysis   •  Convenient Sizes   FAM Caspase Activity Kit IMI-2315 SR Caspase Activity Kit IMI-2316   MitoGLO™ for Mitochondrial Membrane Potential Detection Mitochondrial depolarization is often associated with early stage apoptosis.  MitoGLO™ may be useful in detecting the early onset of apoptosis. IMGENEX offers MitoGLO™, a JC-1 based assay system optimized for cultured cells.  MitoGLO™ can be used in a number of applications including flow cytometry, fluorescence microscopy, and in 96-well fluorescence plate readers.   As the concentration of MitoGLO™ increases within polarized mitochondria, J-aggregates form which fluoresce red. In cells containing mitochondria undergoing depolarization, MitoGLO™ does not remain sequestered within the mitochondria but is distributed throughout the cytoplasm in its monomeric form (green).   CytoGLO™ Annexin V-FITC Apoptosis Detection Kit IMGENEX offersThe CytoGLO™ Annexin V-FITC Apoptosis Kit which is designed for detecting cell death in unfixed cell populations by flow cytometry. The inclusion of stable, positive control cells in the CytoGLO™ Annexin V-FITC Apoptosis Kit makes it unique among other commercially available Annexin V Kits.